Ro-31-8425-CAS 131848-97-0-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀= 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC₅₀= 8 nM for PKC_α, 8 nM for PKC_βI, 14 nM for PKC_βII, 13 nM for PKC_γ, and 39 nM for PKC_ε). Shows slight selectivity for the conventional PKC isozymes PKC_α, PKC_β, and PKC_γover the Ca²⁺-independent PKC isozyme PKC_ε. Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.
A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC₅₀= 15 nM for rat brain PKC). Exhibits some degree of isozyme specificity (IC₅₀= 8 nM for PKC_α, 8 nM for PKC_βI, 14 nM for PKC_βII, 13 nM for PKC_γ, and 39 nM for PKC_ε). Upregulates CD11a expression and enhances mesenchymal stromal cell adhesion under flow.

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Target IC₅₀: 15 nM for rat brain PKC; 8 nM for PKCα, 8 nM for PKCβI, 14 nM for PKCβII, 13 nM for PKCγ, and 39 nM for PKCε
Product competes with ATP.
Reversible: yes
Primary Target
PKC

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Levy, O., et al. 2015.Cell Reports10,In press.
Merritt, J.E., et al. 1997.Cell Signal9,53.
Wilkinson, S.E., et al. 1993.Biochem. J.294,335.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

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