半岛bd体育手机客户端 说明
一般描述
A potent, cell-permeable, reversible, and ATP-competitive cRAF1 kinase inhibitor (IC50= 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-Src, ERK2, MEK, p38, Tie2, VEGFR2, and c-Fms. Predicted broad spectrum antitumor agents. A 10 mM (500 ?g/96 ?l) solution of Raf1 Inhibitor I (Cat. No. 553003) in DMSO is also available.
A potent, cell-permeable, reversible, and ATP-competitive cRaf1 kinase inhibitor (IC50= 9 nM). Shows ≥100-fold selectivity for Raf kinase versus Cdk1, Cdk2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms. cRaf1 inhibitors are predicted to be broad spectrum antitumor agents.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
CRAFI kinase
Product competes with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
From Catalog:
Desc. Field- added "Predicted broad spectrum antitumor agents."
其他说明
Lackey, K., et al. 2000.Bioorg. Med. Chem. Lett.10,223.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C15H8Br2INO2 |
| 分子量 | 520.94 |
| MDL编号 | MFCD03453076 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| 效能 | 9 nM IC50 |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | dark orange |
| 溶解性 | DMSO: 200 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
Sigma-Aldrich
m.cnreagent.com
