PDGFR Tyrosine Kinase Inhibitor IV-CAS 627518-40-5-Calbiochem

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一般描述

A cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC₅₀<33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC₅₀= 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC₅₀= 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC₅₀= 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk′s-1,-2,-4 &-7, bFGFR-1 and EGFR (IC₅₀= 3.1 ?M, >10 ?M, >10 ?M, 45.8 ?M and >100 ?M, respectively).

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Target IC₅₀: 4.2 nM and 45 nM for -β and -α form of PDGFR, respectively
Product competes with ATP.
Primary Target
PDGFR Tyrosine Kinase
Reversible: yes

警告

Toxicity: Harmful (C)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Ho, C.Y., et al. 2005.J. Med. Chem.48,8163.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

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