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位置: 首页> 品牌> Sigma-Aldrich> p53 Activator III, RITA-CAS 213261-59-7-Calbiochem

p53 Activator III, RITA-CAS 213261-59-7-Calbiochem

品牌
Sigma-Aldrich
CAS
213261-59-7
货号
506149
规格纯度
The p53 Activator III, RITA, also referenced under CAS 213261-59-7, modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
价格
1387.85 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
213261-59-7
p53 Activator III, RITA-CAS 213261-59-7-Calbiochem
NSC 652287, 2,5- bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis, MDM2 Antagonist VII, MDM2 Inhibitor X
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 ?M) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip)in vivo.
A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 ?M) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip)in vivo.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
p53
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Grinkevich, V., et al. 2005.Nat. Med.11,1136.
Krajewski, M., et al. 2005.Nat. Med.11,1135.
Issaeva, N., et al. 2004.Nat. Med.10,1321.
Nieves-Neira, W., et al. 1999.Mol. Pharmacol.56,478.
Rivera, M.I., et al. 1999.Biochem. Pharmacol.57,1283.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式 C14H12O3S2
分子量 292.37

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥97% (HPLC)
形式 crystalline solid
manufacturer/tradename Calbiochem?
储存条件 OK to freeze
protect from light
溶解性 ethanol: 1 mg/mL
DMSO: 3 mg/mL
运输 ambient
储存温度 2-8℃
InChI 1S/C14H12O3S2/c15-7-9-1-5-13(18-9)11-3-4-12(17-11)14-6-2-10(8-16)19-14/h1-6,15-16H,7-8H2
InChI key KZENBFUSKMWCJF-UHFFFAOYSA-N

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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