Myeloperoxidase Inhibitor-I-CAS 5351-17-7-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀= 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.
A benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC₅₀= 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC₅₀= 16 ?M and 2.2 ?M, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H₂O₂-treated HL-60 promyelocytic leukemia cells.

包装

1 g in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Reversible: no
Target IC₅₀: 300 nM against myeloperoxidase (MPO)
Cell permeable: no
Primary Target
Myeloperoxidase

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Engelmann, I., et al. 2000.Redox Report5,207.
Wagner, B.A., et al. 2000.J. Biol. Chem.275,22461.
Burner, U., et al. 1999.J. Biol. Chem.274,9494.
Kettle, A.J., et al. 1997.Biochem. J.321,503.
Kettle, A.J., et al. 1995.Biochem. J.308,559.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C7H9N3O
分子量	151.17
MDL编号	MFCD00007606

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	beige
溶解性	DMSO: 10 mg/mL dilute acid: soluble
运输	ambient
储存温度	?20℃
InChI	1S/C7H9N3O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,8-9H2,(H,10,11)
InChI key	WPBZMCGPFHZRHJ-UHFFFAOYSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable