半岛bd体育手机客户端 说明
一般描述
A cell-permeablecis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50= 90 nM for Nutlin-3a and 13.6 ?M for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 ?l) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
A cell-permeable, potent, and selective MDM2 antagonist (IC50= 90 nM for Nutlin-3a and 13.6 ?M for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Primary Target
MDM2
Target IC50: 90 nM for Nutlin-3a and 13.6 ?M for Nutlin-3b
Product does not compete with ATP.
Reversible: no
警告
Toxicity: Harmful (C)
重悬
Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他说明
Thompson, T., et al. 2004.J. Biol. Chem.279,53015.
Vassilev, L.T., et al. 2004.Science303,844.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C30H30Cl2N4O4 |
| 分子量 | 581.49 |
| MDL编号 | MFCD07784509 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (TLC and HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 溶解性 | DMSO: 25 mg/mL ethanol: 25 mg/mL |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| InChI | 1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37) |
| InChI key | BDUHCSBCVGXTJM-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
