半岛bd体育手机客户端 说明
一般描述
A cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activation presumably by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC50= 625 nM) and cell proliferation (IC50<1.25 ?M) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K.
包装
1 mg in Plastic ampoule
Packaged under inert gas
Please refer to vial label for lot-specific concentration.
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Primary Target
Akt
Target IC50: 625 nM and <1.25 ?M in blocking Akt-mediated FOXO1a nuclear export and cell proliferation, respectively, in 786-O cells
Reversible: yes
警告
Toxicity: Irritant (B)
外形
A 10 mM (1 mg/163 ?l) solution of Akt Inhibitor IV (Cat. No. 124011) in DMSO.
重悬
Following initial use, aliquot and refrigerate (4°C).
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C31H27IN4S |
| 分子量 | 614.54 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | liquid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) protect from light |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 2 |
| 闪点(F) | 188.6 °F - (Dimethylsulfoxide) |
| 闪点(C) | 87 ℃ - (Dimethylsulfoxide) |
Sigma-Aldrich
m.cnreagent.com
