半岛bd体育手机客户端 说明
一般描述
A potent, reversible, and selective inhibitor of Cdk1 (IC50= 5 nM) and Cdk5 (IC50= 7 nM) and glycogen synthase kinase-3β (GSK-3β; IC50= 80 nM). The inhibition is competitive with respect to ATP.
A highly potent, reversible, and selective inhibitor of cyclin-dependent kinases 1 and 5 (IC50= 5 nM for CDK1; IC50= 7 nM for CDK5). Reported to act by competing with ATP for binding to the catalytic site of the kinase. Also acts as a potent inhibitor of glycogen synthase kinase-3β (GSK-3β; IC50= 80 nM).
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
CDK1
Product competes with ATP.
Target IC50: 5 nM, 7 nM, 80 nM, against Cdk1, Cdk5, and glycogen synthase kinase-3β (GSK-3β), respectively
Cell permeable: no
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 4 months at -20°C.
其他说明
Leclerc, S., et al. 2001.J. Biol. Chem.276,251.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H11N3O5S |
| 分子量 | 357.34 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥97% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | dark red |
| 溶解性 | DMSO: 50 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
