半岛bd体育手机客户端 说明
一般描述
A potent cell-permeable, reversible, and ATP-compatible inhibitor of glycogen synthase kinase-3β (IC50= 22 nM) and cyclin-dependent kinases (IC50= 180 nM for Cdk1 and 100 nM for Cdk5). Inhibits the proliferation of a large range of cells by arresting them in the G2/M phase of the cell cycle. Inhibits Tau phosphorylationin vitroandin vivoat Alzheimer′s disease-specific sites. Also reported to inhibit thein vivophosphorylation of DARPP-32 by Cdk5 on Thr75.
A potent, reversible, and ATP-compatible inhibitor of GSK-3β (glycogen synthase kinase 3β), Cdk1 (cyclin-dependent kinase1) and Cdk5 (IC50= 22 nM, 180 nM, and 100 nM, respectively). Inhibits the proliferation of a large range of cells by arresting them in the G2/M phase of the cell cycle. Inhibits Tau phosphorylationin vitroandin vivoat Alzheimer’s disease-specific sites. Also reported to inhibit thein vivophosphorylation of DARPP-32 by Cdk5 on Thr75.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Target IC50: 22 nM, 180 nM, and 100 nM against GSK-3β, Cdk1, and Cdk5, respectively
Primary Target
Gsk-3β
Product competes with ATP.
Reversible: yes
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Bain, J., et al. 2003. Biochem. J. 371, 199.
Leclerc, S., et al. 2000.J. Biol. Chem.276,251.
Hoessel, R., et al. 1999.Nat. Cell Biol.1,60.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H11N3O2 |
| 分子量 | 277.28 |
| MDL编号 | MFCD02683594 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze protect from light |
| 颜色 | dark red |
| 溶解性 | DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
