IKK Inhibitor II, Wedelolactone-CAS 524-12-9-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Cell-permeable. The naturally-occuring active ingredient from the herbal medicine,Eclipta alba, that acts as a selective and irreversible inhibitor of IKKα and IKKβ kinase activities (IC₅₀<10 ?M). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Does not affect the activities of p38 MAP kinase or Akt.
The naturally isolated active ingredient of the herbal medicine,Eclipta alba, that acts as a cell permeable, selective and irreversible inhibitor of IKKα and β kinase activity (IC₅₀<10 ?M). Inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Has no effects on p38 MAP kinase or Akt.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
IKKα and β kinase activity
Target IC₅₀: <10 ?M against IKKα and β kinase activity
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Kobori, M., et al. 2004.Cell Death Differ.11,123.
Li, C.C., et al. 2003.J. Org. Chem.68,8500.
Mors, W.B., et al. 1989.Toxicon27,1003.
Wagner, H., and Fessler, B. 1986.Planta Med.5,374.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C16H10O7
分子量	314.25
MDL编号	MFCD07778564

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	crystalline powder
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	yellow-green
溶解性	methanol: 1 mg/mL DMSO: 5 mg/mL
运输	ambient
储存温度	2-8℃
InChI	1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
InChI key	XQDCKJKKMFWXGB-UHFFFAOYSA-N

安全信息

象形图
警示用语：	Warning
危险声明	H302
预防措施声明	P264 - P270 - P301 + P312 - P501
危险分类	Acute Tox. 4 Oral
储存分类代码	11 - Combustible Solids
WGK	WGK 1