半岛bd体育手机客户端 说明
一般描述
A cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50= 40 ?M). Does not affect the activities of Cdc-2, PKB, or PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~ 2.5-fold) in HEK293 cells. Also reported to improve glucose tolerance in diabetic mice. Exhibits greaterin vivostability.
A cell-permeable myristoylated form of GSK-3β Peptide Inhibitor (Cat. No. 361545) with a glycine spacer. Acts as a selective, substrate-specific, competitive inhibitor of GSK-3β (IC50= 40 ?M). Does not affect the activities of Cdc2, PKB, and PKC. Shown to mimic insulin action, and activate glycogen synthase activity (~2.5-fold) in HEK293 cells and improve glucose tolerance in diabetic mice. Displaysin vivostability.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Reversible: no
Target IC50: 40 ?M against Gsk-3β
警告
Toxicity: Standard Handling (A)
序列
Myr-N-Gly-Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-Ser(PO?H)-Pro-NH?
其他说明
Plotkin, B., et al. 2003.J. Pharmacol. Exp. Ther.305,974.
法律信息
This product is covered by one or more US patents and/or patent applications and foreign counter-parts owned by Tel Aviv University Future Technology LP, a limited partnership formed under the laws of Israel. Purchase of this product conveys a non-exclusive license to use the product for research purposes only. Purchase of this product does not convey the right to (i) incorporate or use the product in the manufacture of any commercial product, (ii) sell or otherwise transfer the product to any third party, or (iii) use the product to provide any commercial service. THE PRODUCT IS NOT FOR USE IN HUMANS. For information on purchasing a license to this product for purposes other than research, contact VP Business Development, Ramot at Tel Aviv University Ltd., Tel Aviv University, Licensor-Aviv, Tel Aviv 61392, Israel, Phone: +972 3 640 6608; Fax: +972 3 640 6675.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C66H110N15O20P |
| 分子量 | 1464.64 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (HPLC) |
| 形式 | lyophilized solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze desiccated (hygroscopic) |
| 颜色 | white |
| 溶解性 | acetonitrile: water (1:1): 1 mg/mL DMSO: 5 mg/mL |
| 运输 | ambient |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
