GSK-3 Inhibitor IX, Control, MeBIO-CAS 710323-61-8-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as an inactive control for Cdk1/cyclin B, Cdk5/p25, and GSK-3α/β (IC₅₀>92 ?M for Cdk1/cyclin B, >100 ?M for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀= 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.
A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC₅₀>92 ?M for Cdk1/B, >100 ?M for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC₅₀= 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Cell permeable: yes
Primary Target
Relevant kinase inactive control
Product does not compete with ATP.
Reversible: no
Target IC₅₀: >92 ?M for Cdk1/B, >100 ?M for Cdk5/p25, and GSK-3α/β

警告

Toxicity: Standard Handling (A)

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C17H12BrN3O2
分子量	370.20

半岛bd体育手机客户端 性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze protect from light
颜色	dark red
溶解性	DMSO: 10 mg/mL
运输	ambient
储存温度	2-8℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable