D-erythro-Sphingosine-1-phosphate-CAS 26993-30-6-Calbiochem

半岛bd体育手机客户端 说明

一般描述

A putative second messenger that mobilizes calcium from intracellular stores via an IP₃-independent pathway. Activates phospholipase D (PLD) and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss/3T3 fibroblasts. Inhibits activation of caspases that cleave PARP and lamins during Fas- and ceramide-mediated apoptosis.
A putative second messenger that mobilizes calcium from intracellular stores via an IP₃independent pathway. Activates phospholipase D and inhibits chemotactic motility and invasiveness of tumor cells. Also stimulates growth of quiescent Swiss 3T3 fibroblasts.

包装

1 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Product does not compete with ATP.
Reversible: no
Cell permeable: no
Primary Target
Mobilizes calcium from intracellular stores

警告

Toxicity: Irritant (B)

制备说明

Slight warming and vortexing may be required.

重悬

Following reconstitution, aliquot and evaporate under a stream of nitrogen. Store at -20°C. Prior to use, dissolve in 4 mg/ml BSA solution with vortexing. Stock solutions are stable for up to 2 months at -20°C.

其他说明

Cuvillier, O., et al. 1998.J. Biol. Chem.273,2910.
Mattie, M., et al. 1994.J. Biol. Chem.269,3181.
Olivera, A. and Spiegel, S. 1993.Nature365,557.
Desai, N.N., et al. 1992.J. Biol. Chem.267,23122.
Sadahira, Y., et al. 1992.Proc. Natl. Acad. Sci. USA89,9686.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C18H38NO5P
分子量	379.47
MDL编号	MFCD00270077

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (TLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	methanol: 0.5 mg/mL
运输	ambient
储存温度	?20℃
InChI	1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChI key	DUYSYHSSBDVJSM-KRWOKUGFSA-N

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable