Cyclo(Arg-Gly-Asp-D-Phe-Val)-CAS 137813-35-5-Calbiochem

半岛bd体育手机客户端 说明

一般描述

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates.In vivoinvestigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.
Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates.In vivoinvestigations showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion.

包装

1 mg in Plastic ampoule

生化/生理作用

Primary Target
inhibits tumor cell adhesion to laminin and vitronectin substrates
Product does not compete with ATP.
Reversible: no
Cell permeable: no

警告

Toxicity: Standard Handling (A)

其他说明

Shono, T., et al. 2001.Exp. Cell Res.268,169.
Matsuno, H., et al. 1994.Circulation90,2203.
Noiri, E., et al. 1994.Kidney Int.46,1050.
Gurrath, M., et al. 1992.Eur. J. Biochem.210,911.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C26H38N8O7
分子量	574.63

半岛bd体育手机客户端 性质

质量水平	100
测定	≥95% (HPLC)
形式	solid
manufacturer/tradename	Calbiochem?
储存条件	OK to freeze desiccated (hygroscopic)
颜色	white
溶解性	1 N acetic acid: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable