半岛bd体育手机客户端 说明
一般描述
A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app= 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 ?M. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app= 510 nM, 1.2 ?M, respectively). Does not significantly inhibit cathepsin L.
A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki= 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 ?M. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki= 510 nM and 1.2 ?M, respectively). Does not significantly inhibit cathepsin L.
包装
1 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Primary Target
cathepsin K
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Target Ki: 6 nM against cathepsin; 510 nM, 1.2 ?M, against cathepsin B and papain, respectively
警告
Toxicity: Standard Handling (A)
序列
Boc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
其他说明
Wang, D., et al. 2002.Biochemistry41,8849.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C35H51N7O8 |
| 分子量 | 697.82 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥95% (HPLC) |
| 形式 | lyophilized solid |
| manufacturer/tradename | Calbiochem? |
| 储存条件 | OK to freeze |
| 颜色 | white |
| 溶解性 | DMSO: 1 mg/mL |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
