半岛bd体育手机客户端 说明
一般描述
A cell-permeable inhibitor of caspase-1 (ICE; interleukin-1β converting enzyme). The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki= 1 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
A cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (Ki= 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
包装
1 mg in Plastic ampoule
生化/生理作用
Cell permeable: yes
Product does not compete with ATP.
Primary Target
Caspase-1
Reversible: yes
警告
Toxicity: Standard Handling (A)
序列
Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO
重悬
Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
其他说明
Garcia-Calvo, M., et al. 1998.J. Biol. Chem.273,32608.
Hilbi, H., et al. 1998.J. Biol. Chem.273,32895.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
Lin, Y.-Z., et al. 1996.J. Biol. Chem.271,5305.
Lin, Y.-Z., et al. 1995.J. Biol. Chem.270,14255.
Reiter, L.A. 1994.Int. J. Pept. Protein Res.43,87.
Thornberry, N.A., et al. 1994.Biochemistry33,3934.
Thornberry, N.A., et al. 1994.MethodsEnzymol.244,615.
Thornberry, N.A., et al. 1992.Nature356,768.
法律信息
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
经验(实验)分子式 | C97H160N20O24 |
分子量 | 1990.43 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥97% (HPLC) |
形式 | solid |
效能 | 1 nM Ki |
manufacturer/tradename | Calbiochem? |
储存条件 | OK to freeze |
颜色 | white |
溶解性 | DMSO: 5 mg/mL |
运输 | ambient |
储存温度 | ?20℃ |
安全信息
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 1 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich