Caspase-1 Inhibitor I, Cell-Permeable-Calbiochem

品牌

Sigma-Aldrich

货号

400011

包装型号

1 MG, The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

规格纯度

The Caspase-1 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

价格

3806.77 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

Caspase-1 Inhibitor I, Cell-Permeable-Calbiochem
ICE Inhibitor I, Cell-permeable, YVAD-CHO, Cell-permeable, Ac-AAVALLPAVLLALLAPYVAD-CHO

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

一般描述

A cell-permeable inhibitor of caspase-1 (ICE; interleukin-1β converting enzyme). The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (K_i= 1 nM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
A cell-permeable inhibitor of caspase-1 (ICE; Interleukin-1β Converting Enzyme), caspase-4, and caspase-5. The C-terminal YVAD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-1 (K_i= 1 nM). The N-terminal sequence (amino acid residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of the Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.

包装

1 mg in Plastic ampoule

生化/生理作用

Cell permeable: yes
Product does not compete with ATP.
Primary Target
Caspase-1
Reversible: yes

警告

Toxicity: Standard Handling (A)

序列

Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Tyr-Val-Ala-Asp-CHO

重悬

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

其他说明

Garcia-Calvo, M., et al. 1998.J. Biol. Chem.273,32608.
Hilbi, H., et al. 1998.J. Biol. Chem.273,32895.
Thornberry, N.A., and Lazebnik, Y. 1998.Science281,1312.
Lin, Y.-Z., et al. 1996.J. Biol. Chem.271,5305.
Lin, Y.-Z., et al. 1995.J. Biol. Chem.270,14255.
Reiter, L.A. 1994.Int. J. Pept. Protein Res.43,87.
Thornberry, N.A., et al. 1994.Biochemistry33,3934.
Thornberry, N.A., et al. 1994.MethodsEnzymol.244,615.
Thornberry, N.A., et al. 1992.Nature356,768.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式	C₉₇H₁₆₀N₂₀O₂₄
分子量	1990.43

半岛bd体育手机客户端性质

质量水平	100
测定	≥97% (HPLC)
形式	solid
效能	1 nM K_i
manufacturer/tradename	Calbiochem^?
储存条件	OK to freeze
颜色	white
溶解性	DMSO: 5 mg/mL
运输	ambient
储存温度	?20℃

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable