半岛bd体育手机客户端 说明

一般描述

A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC₅₀= 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC₅₀= 411 nM) and three other MAPKKKs (IC₅₀≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H₂O₂-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol,Curvulariasp.(Cat. No. 499609) may serve as a negative control.
A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC₅₀= 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC₅₀= 411 nM) and three other MAPKKKs (IC₅₀≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H₂O₂-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol,Curvulariasp. (Cat. No. 499609) may serve as a negative control.

包装

1 mg in Glass bottle

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Windheim, M., et al. 2007.Biochem. J.404,179.
Choo, M.K., et al. 2006.Mol. Cancer Ther.5,2970.
Safwat, N., et al. 2005.Endocrinology146,4814.
Ninomiya-Tsuji, J., et al. 2003.J. Biol. Chem.278,18485.
Rawlins, P., et al. 1999.Int. J. Immunopharmacol.21,799.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

半岛bd体育手机客户端 性质

安全信息