Monoclonal Anti-IGFBP1 antibody produced in mouse

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一般描述

Insulin-like growth factor binding protein 1 (IGFBP1) is a ~30 kDa secretory protein. It is formed mostly in the liver and kidney. IGFBP1 is a member of the IGFBPs family. This gene is located on human chromosome 7p12.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. (provided by RefSeq)

免疫原

IGFBP1 (NP_000587, 160 a.a. ~ 259 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
GSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN

生化/生理作用

Insulin-like growth factor binding protein 1 (IGFBP1) participates in the modulation of fetal growth through the insulin-like growth factor axis. Due to its high-affinity binding, IGFBP1 also controls the IGF bioactivity. It has the capability to bind and regulate the bioavailability of circulating insulin-like growth factors (IGFs).

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

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