Monoclonal Anti-CNR2 antibody produced in mouse

半岛bd体育手机客户端 说明

一般描述

The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. (provided by RefSeq)
Cannabinoid receptor 2 (CNR2) is encoded by the gene mapped to human chromosome 1p36.11. The encoded protein belongs to a novel cadherin-related multigene family. Members of this family contain six cadherin repeats and conserved DXNDNXPXF and DXD motifs with constitute putative calcium-binding sequences.

免疫原

CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC

应用

Monoclonal Anti-CNR2 antibody produced in mouse has been used in western blot analysis.

生化/生理作用

Cannabinoid receptor 2 (CNR2) plays a crucial role in mediating anti-inflammatory and anti-atherosclerotic effectsin vivo. It is also involved in cancer, bone metabolism and pain perception. CNR2 might be implicated in selective cell–cell interaction. Mutations in the gene has been associated with trochanter and hip bone mineral density (BMD).

外形

Solution in phosphate buffered saline, pH 7.4

法律信息

GenBank is a registered trademark of United States Department of Health and Human Services

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
偶联物	unconjugated
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	3C7, monoclonal
形式	buffered aqueous solution
species reactivity	human
technique(s)	immunofluorescence: suitable indirect ELISA: suitable western blot: 1-5 μg/mL
同位素/亚型	IgG1κ
GenBank?accession no.	NM_001841.1
UniProt登记号	P34972
运输	dry ice
储存温度	?20℃
Gene Information	human ... CNR2(1269)

安全信息

储存分类代码	12 - Non Combustible Liquids
闪点(F)	Not applicable
闪点(C)	Not applicable
个人防护装备	Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)