浜у搧璇存槑
涓€鑸弿杩?/p>
Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. Human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones. Anti-thyroglobulin reacts with human thyroglobulin as demonstrated by a single band of immunoblotting in a lysate of human thyroid tissue. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
鑱旂郴
Thyroglobulin Positive Control Slides, Product No. 340S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
澶栧舰
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
鍏朵粬璇存槑
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
娉曞緥淇℃伅
Cell Marque is a trademark of sigma-aldrich Co. LLC
鍩烘湰淇℃伅
NACRES | NA.41 |
浜у搧鎬ц川
璐ㄩ噺姘村钩 | 500 100 |
鐢熺墿鏉ユ簮 | mouse |
鍋惰仈鐗?/td> | unconjugated |
鎶椾綋褰㈠紡 | diluted ascites fluid |
antibody product type | primary antibodies |
鍏嬮殕 | 2H11+6E1, monoclonal |
鎻忚堪 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
褰㈠紡 | buffered aqueous solution |
species reactivity | human |
鍖呰 | vial of 0.1 mL concentrate (340M-14) vial of 0.5 mL concentrate (340M-15) bottle of 1.0 mL predilute (340M-17) vial of 1.0 mL concentrate (340M-16) bottle of 7.0 mL predilute (340M-18) |
manufacturer/tradename | Cell Marque? |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
鍚屼綅绱?浜氬瀷 | IgG1 |
鎺у埗 | thyroid |
杩愯緭 | wet ice |
鍌ㄥ瓨娓╁害 | 2-8鈩傸/td> |
鍙鍖朁/td> | cytoplasmic |