半岛bd体育手机客户端 说明
一般描述
Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. Human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones. Anti-thyroglobulin reacts with human thyroglobulin as demonstrated by a single band of immunoblotting in a lysate of human thyroid tissue. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
联系
Thyroglobulin Positive Control Slides, Product No. 340S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 500 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | diluted ascites fluid |
| antibody product type | primary antibodies |
| 克隆 | 2H11+6E1, monoclonal |
| 描述 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | vial of 0.1 mL concentrate (340M-14) vial of 0.5 mL concentrate (340M-15) bottle of 1.0 mL predilute (340M-17) vial of 1.0 mL concentrate (340M-16) bottle of 7.0 mL predilute (340M-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
| 同位素/亚型 | IgG1 |
| 控制 | thyroid |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| 可视化 | cytoplasmic |
Sigma-Aldrich
m.cnreagent.com
