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Thyroglobulin (2H11+6E1) Mouse Monoclonal Antibody

鍝佺墝
Sigma-Aldrich
璐у彿
340M-1
鍖呰鍨嬪彿
瑙勬牸绾害
鍙傝€冧环鏍稽/div>
2074.28 鍏傸/span>*鏈环鏍煎惈澧炲€肩◣璐更/span>
淇冮攢
鏈嶅姟
  • 鈭欬/span>鍘熷巶淇濊瘉
  • 鈭欬/span>鍖呴偖
  • 鈭欬/span>澧炲€肩◣绁?/li>
鏁伴噺
- +
浜у搧鍚嶇О锛欬/div>
Thyroglobulin (2H11+6E1) Mouse Monoclonal Antibody
浜у搧浠嬬粛锛欬/div>

浜у搧璇存槑

涓€鑸弿杩?/p>

Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. Human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones. Anti-thyroglobulin reacts with human thyroglobulin as demonstrated by a single band of immunoblotting in a lysate of human thyroid tissue. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

鑱旂郴

Thyroglobulin Positive Control Slides, Product No. 340S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

澶栧舰

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

鍏朵粬璇存槑

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

娉曞緥淇℃伅

Cell Marque is a trademark of sigma-aldrich Co. LLC

鍩烘湰淇℃伅

NACRES NA.41

浜у搧鎬ц川

璐ㄩ噺姘村钩 500
100
鐢熺墿鏉ユ簮 mouse
鍋惰仈鐗?/td> unconjugated
鎶椾綋褰㈠紡 diluted ascites fluid
antibody product type primary antibodies
鍏嬮殕 2H11+6E1, monoclonal
鎻忚堪 For In Vitro Diagnostic Use in Select Regions (See Chart)
褰㈠紡 buffered aqueous solution
species reactivity human
鍖呰 vial of 0.1 mL concentrate (340M-14)
vial of 0.5 mL concentrate (340M-15)
bottle of 1.0 mL predilute (340M-17)
vial of 1.0 mL concentrate (340M-16)
bottle of 7.0 mL predilute (340M-18)
manufacturer/tradename Cell Marque?
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
鍚屼綅绱?浜氬瀷 IgG1
鎺у埗 thyroid
杩愯緭 wet ice
鍌ㄥ瓨娓╁害 2-8鈩傸/td>
鍙鍖朁/td> cytoplasmic

Sigma-Aldrich

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