浜у搧璇存槑
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Smoothelin is a constituent of the smooth muscle cell cytoskeleton protein exclusively found in differentiated smooth muscle cells (SMC). Cells with SMC-like characteristics, such as myofibroblasts and myoepithelial cells, as well as skeletal and cardiac muscle do not contain smoothelin. To distinguish bladder muscularis mucosae (MM) from muscularis propria (MP) muscle bundles is crucial for accurate staging of bladder carcinoma. Strong smoothelin expression is nearly exclusively observed in muscularis propria. Therefore, the staining pattern of MP (strongly positive) and MM (negative or weakly positive) makes this technique an attractive diagnostic tool for the sometimes difficult task of staging bladder urothelial carcinoma, such as in transurethral resection specimens of urinary bladder tumors. Differentiating between smooth muscle tumors and other mesenchymal neoplasms of the GI tract can be challenging in small biopsies. Anti-smoothelin immunostaining can be helpful in differentiating benign (+) from malignant smooth muscle tumors (-), and other mimics(-).
璐ㄩ噺
 IVD |
 IVD |
 IVD |
 RUO |
鑱旂郴
Smoothelin Positive Control Slides, Product No. 377S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
澶栧舰
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
鍒跺璇存槑
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鍏朵粬璇存槑
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
娉曞緥淇℃伅
Cell Marque is a trademark of sigma-aldrich Co. LLC
鍩烘湰淇℃伅
| NACRES | NA.41 |
浜у搧鎬ц川
| 璐ㄩ噺姘村钩 | 500 100 |
| 鐢熺墿鏉ユ簮 | mouse |
| 鍋惰仈鐗?/td> | unconjugated |
| 鎶椾綋褰㈠紡 | diluted ascites fluid |
| antibody product type | primary antibodies |
| 鍏嬮殕 | R4A, monoclonal |
| 鎻忚堪 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 褰㈠紡 | buffered aqueous solution |
| species reactivity | human |
| 鍖呰 | vial of 0.1 mL concentrate (377M-14) vial of 0.5 mL concentrate (377M-15) bottle of 1.0 mL predilute (377M-17) vial of 1.0 mL concentrate (377M-16) bottle of 7.0 mL predilute (377M-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
| 鍚屼綅绱?浜氬瀷 | IgG1 |
| 鎺у埗 | bladder, leiomyoma |
| 杩愯緭 | wet ice |
| 鍌ㄥ瓨娓╁害 | 2-8鈩傸/td> |
| 鍙鍖朁/td> | cytoplasmic, nuclear |
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