Phosphohistone H3 (PHH3) Rabbit Polyclonal Antibody

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涓€鑸弿杩?/p>

Phosphohistone H3 (PHH3) is a core histone protein, which together with other histones, forms the major protein constituents of the chromatin in eukaryotic cells. In mammalian cells, phosphohistone H3 is negligible during interphase but reaches a maximum for chromatin condensation during mitosis. Immunohistochemical studies showed anti-PHH3 specifically detected the core protein histone H3 only when phosphorylated at serine 10 or serine 28. Studies have also revealed no phosphorylation on the histone H3 during apoptosis. Therefore, PHH3 can serve as a mitotic marker to separate mitotic figures from apoptotic bodies and karyorrhectic debris, which may be a very useful tool in diagnosis of tumor grades, especially in CNS, skin, gyn., soft tissue, and GIST.

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IVD

RUO

鑱旂郴

Phosphohistone H3 (PHH3) Positive Control Slides, Product No. 369S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

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For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

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Cell Marque is a trademark of sigma-aldrich Co. LLC

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NACRES

NA.41

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鐢熺墿鏉ユ簮	rabbit
璐ㄩ噺姘村钩	500 100
鍋惰仈鐗?/td>	unconjugated
鎶椾綋褰㈠紡	Ig fraction of antiserum
antibody product type	primary antibodies
鍏嬮殕	polyclonal
鎻忚堪	For In Vitro Diagnostic Use in Select Regions (See Chart)
褰㈠紡	buffered aqueous solution
species reactivity	human
鍖呰	vial of 0.1 mL concentrate (369A-14) vial of 0.5 mL concentrate (369A-15) bottle of 1.0 mL predilute (369A-17) vial of 1.0 mL concentrate (369A-16) bottle of 7.0 mL predilute (369A-18)
manufacturer/tradename	Cell Marque^?
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
鎺у埗	tonsil
杩愯緭	wet ice
鍌ㄥ瓨娓╁害	2-8鈩傸/td>
鍙鍖朁/td>	nuclear