浜у搧璇存槑
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p21 is a nuclear 21 kD protein, a product of the WAF1/CIP1 gene. It is a cyclin-dependent kinase inhibitor 1A (p21, Cip1), also known as CDKN1A, which in humans is encoded by the CDKN1A gene located on chromosome (6p21.2). It is a constituent of a large complex of nuclear proteins, including cyclins, cyclin dependent kinases, and PCNA. Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 inhibits the activity of each member of the cyclin/Cdk family. The expression of this gene acts as an inhibitor of the cell cycle during G1 phase and is tightly controlled by the tumor suppressor protein p53. Normal cells generally display a rather intense nuclear p21 expression. Loss of p21 expression has been reported in many carcinomas (gastric carcinoma, non-small cell lung carcinoma, thyroid carcinoma).
璐ㄩ噺
 IVD |
 IVD |
 IVD |
 RUO |
鑱旂郴
p21WAF1 Positive Control Slides, Product No. 421S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
澶栧舰
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
鍒跺璇存槑
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鍏朵粬璇存槑
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
娉曞緥淇℃伅
Cell Marque is a trademark of sigma-aldrich Co. LLC
鍩烘湰淇℃伅
| NACRES | NA.41 |
浜у搧鎬ц川
| 璐ㄩ噺姘村钩 | 500 100 |
| 鐢熺墿鏉ユ簮 | mouse |
| 鍋惰仈鐗?/td> | unconjugated |
| 鎶椾綋褰㈠紡 | diluted ascites fluid |
| antibody product type | primary antibodies |
| 鍏嬮殕 | DCS-60.2, monoclonal |
| 鎻忚堪 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 褰㈠紡 | buffered aqueous solution |
| species reactivity | human |
| 鍖呰 | vial of 0.1 mL concentrate (421M-14) vial of 0.5 mL concentrate (421M-15) bottle of 1.0 mL predilute (421M-17) vial of 1.0 mL concentrate (421M-16) bottle of 7.0 mL predilute (421M-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 |
| 鍚屼綅绱?浜氬瀷 | IgG2a |
| 鎺у埗 | colon |
| 杩愯緭 | wet ice |
| 鍌ㄥ瓨娓╁害 | 2-8鈩傸/td> |
| 鍙鍖朁/td> | nuclear |
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