p120 Catenin (MRQ-5) Mouse Monoclonal Antibody

浜у搧璇存槑

涓€鑸弿杩?/p>

p120 catenin is encoded on chromosome 11q11. Alpha-catenin and beta-catenin bind to the intracellular domain of E-cadherin while p120 catenin binds E-cadherin at a juxta-membrane site. The complex stabilizes tight junctions. In the cell, p120 catenin localized to the E-cadherin/catenins cell adhesion complex, directly associates with cytoplasmic C-terminus of E-cadherin and may similarly interact with other cadherins. A deficiency of E-cadherin results in the intracytoplasmic accumulation of p120 catenin. Lobular carcinoma of the breast shows intracytoplasmic accumulation of p120 catenin while ductal carcinoma shows reduced membrane p120 catenin without cytoplasmic accumulation. In gastric and colonic carcinoma, strong cytoplasmic p120 catenin is associated with discohesive infiltrative morphology.

璐ㄩ噺

IVD

RUO

鑱旂郴

p120 Catenin Positive Control Slides, Product No. 420S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

澶栧舰

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

鍒跺璇存槑

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鍏朵粬璇存槑

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

娉曞緥淇℃伅

Cell Marque is a trademark of sigma-aldrich Co. LLC

鍩烘湰淇℃伅

NACRES

NA.41

浜у搧鎬ц川

璐ㄩ噺姘村钩	500 100
鐢熺墿鏉ユ簮	mouse
鍋惰仈鐗?/td>	unconjugated
鎶椾綋褰㈠紡	culture supernatant
antibody product type	primary antibodies
鍏嬮殕	MRQ-5, monoclonal
鎻忚堪	For In Vitro Diagnostic Use in Select Regions (See Chart)
褰㈠紡	buffered aqueous solution
species reactivity	human
鍖呰	vial of 0.1 mL concentrate (420M-14) vial of 0.5 mL concentrate (420M-15) bottle of 1.0 mL predilute (420M-17) vial of 1.0 mL concentrate (420M-16) bottle of 7.0 mL predilute (420M-18)
manufacturer/tradename	Cell Marque^?
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
鍚屼綅绱?浜氬瀷	IgG1
鎺у埗	lobular breast carcinoma
杩愯緭	wet ice
鍌ㄥ瓨娓╁害	2-8鈩傸/td>
鍙鍖朁/td>	cytoplasmic