浜у搧璇存槑
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Mucin 4 (MUC4) is a transmembranous glycoprotein. MUC4 is expressed in the cytoplasm of certain epithelial surfaces, such as colonic, breast, and lung epithelia. An abnormal expression of MUC4 has been reported in various carcinomas of the colon, pancreas, breast, and ovaries.MUC4 is highly expressed in the vast majority of human pancreatic neoplasms, such as intraductal papillary mucinous neoplasia of the pancreas, pancreatic intraepithelial neoplasms and pancreatic ductal adenocarcinoma; however, it is not detected in the normal pancreas or in chronic pancreatitis.MUC4 is not expressed in normal bile ducts, but it can be overexpressed in intrahepatic cholangiocarcinoma and bile duct cholangiocarcinoma. MUC4 overexpression has been reported in low-grade fibromyxoid sarcoma (LGFMS). In this study a large cohort of LGFMS, all with FUS gene rearrangement confirmed by FISH, showed cytoplasmic staining for MUC4, usually in a strong and diffuse manner. Similarly, strong, diffuse cytoplasmic staining for MUC4 was identified in 78% (32/41) of cases of sclerosing epithelioid fibrosarcoma. MUC4 expression is also detected in the glandular component of biphasic synovial sarcomas (90%). Focal staining, usually interpreted as only scattered cells, was also seen in a subset of ossifying fibromyxoid tumors (29%), epithelioid GISTs (20%) and myoepithelial carcinomas (10%); whereas all other epithelioid soft tissue tumors鈥攊ncluding clear cell sarcoma, epithelioid sarcoma, epithelioid hemangiosarcoma, PEComa and melanoma鈥攚ere negative. It should be noted that various carcinomas may express MUC4, and therefore additional keratins or lineage-specific markers may be needed to exclude this possibility in some cases.
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 IVD |
 IVD |
 IVD |
 RUO |
鑱旂郴
MUC4 Positive Control Slides, Product No. 406S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
澶栧舰
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
鍒跺璇存槑
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For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
娉曞緥淇℃伅
Cell Marque is a trademark of sigma-aldrich Co. LLC
鍩烘湰淇℃伅
| NACRES | NA.41 |
浜у搧鎬ц川
| 璐ㄩ噺姘村钩 | 500 100 |
| 鐢熺墿鏉ユ簮 | mouse |
| 鍋惰仈鐗?/td> | unconjugated |
| 鎶椾綋褰㈠紡 | culture supernatant |
| antibody product type | primary antibodies |
| 鍏嬮殕 | 8G7, monoclonal |
| 鎻忚堪 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 褰㈠紡 | buffered aqueous solution |
| species reactivity | human |
| 鍖呰 | vial of 0.1 mL concentrate (406M-14) vial of 0.5 mL concentrate (406M-15) bottle of 1.0 mL predilute (406M-17) vial of 1.0 mL concentrate (406M-16) bottle of 7.0 mL predilute (406M-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50 |
| 鍚屼綅绱?浜氬瀷 | IgG1κ |
| 鎺у埗 | colon, colorectal adenocarcinoma, pancreatic ductal adenocarcinoma |
| 杩愯緭 | wet ice |
| 鍌ㄥ瓨娓╁害 | 2-8鈩傸/td> |
| 鍙鍖朁/td> | cytoplasmic |
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