Carbonic Anhydrase IX (CA IX) (EP161) Rabbit Monoclonal Primary Antibody

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Carbonic anhydrases are a family of zinc containing metalloproteins that catalyze the reversible hydration of CO₂. Among these, carbonic anhydrase IX (CA IX) is anchored to the cell membrane and is expressed in the human gastrointestinal tract, chiefly in the stomach and gall bladder¹. It is interesting to note that CA IX is overexpressed in epithelial malignancies of the uterus, cervix, lung, breast, and kidney; none of the associated normal tissues express this isozyme.^1-4CA IX is said to maintain the extracellular acidic pH, thus promoting cell growth in these tumors.⁵Preliminary data suggest consistent immunoreactivity for anti-CA IX in clear cell renal cell carcinoma (RCC) with demonstrated sensitivity of 85% to 100%.²Anti-CA IX, together with antibodies against PAX-2, Ksp-cadherin, and CD117, contributes to a robust panel that can be used to help make this distinction. Strong diffuse-to-multifocal immunostaining for anti-CA IX is observed in the large majority of urothelial carcinomas as opposed to the extremely weak and focal immunoreactivity seen in collecting duct carcinoma (CDC). Anti-CA IX can thus aid in distinguishing between urothelial carcinoma and CDC.⁶

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IVD

RUO

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Carbonic Anhydrase IX (CA IX) Positive Control Slides, Product No. 379S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

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Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

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NACRES

NA.41

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鐢熺墿鏉ユ簮	rabbit
璐ㄩ噺姘村钩	500 100
鍋惰仈鐗?/td>	unconjugated
鎶椾綋褰㈠紡	culture supernatant
antibody product type	primary antibodies
鍏嬮殕	EP161, monoclonal
鎻忚堪	(For In Vitro Diagnostic Use in Select Regions (See Chart))
褰㈠紡	buffered aqueous solution
species reactivity	human
鍖呰	bottle of 1.0 mL predilute (379R-17) bottle of 7.0 mL predilute (379R-18) vial of 0.1 mL concentrate (379R-14) vial of 0.5 mL concentrate (379R-15) vial of 1.0 mL concentrate (379R-16)
manufacturer/tradename	Cell Marque^?
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
鍚屼綅绱?浜氬瀷	IgG
杩愯緭	wet ice
鍌ㄥ瓨娓╁害	2-8鈩傸/td>