TCL1 (MRQ-7) Mouse Monoclonal Antibody

半岛bd体育手机客户端 说明

一般描述

T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is a 14 kDa product of the TCL1 gene that is involved in T-cell prolymphocytic leukemia (T-PLL). TCL1 protein is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 binds to a novel site in the pleckstrin homology (PH) domain, resulting in activation and nuclear translocation of Akt by overexpressed TCL1 which may promote an anti-apoptotic response; this may normally serve to promote growth during development but may lead to malignancy when TCL1 is overexpressed. TCL1 is expressed in differentiated B-cells under both reactive and neoplastic conditions, antigen committed B-cells, and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation. TCL1 is overexpressed in Burkitt lymphoma, the majority of AIDS-related non-Hodgkin lymphoma-designated immunoblastic plasmacytoid lymphoma, lymphoblastic lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and primary cutaneous B-cell lymphoma. Therefore, the most useful application of anti-TCL1 is the discrimination of B-cell lymphomas from T-cell lymphomas, CD30+ anaplastic large cell lymphomas, multiple myeloma, and marginal zone B-cell lymphoma.

质量

IVD

IVD

IVD

RUO

联系

TCL1 Positive Control Slides, Product No. 357S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES

NA.41

半岛bd体育手机客户端 性质

质量水平	500 100
生物来源	mouse
偶联物	unconjugated
抗体形式	culture supernatant
antibody product type	primary antibodies
克隆	MRQ-7, monoclonal
描述	For In Vitro Diagnostic Use in Select Regions (See Chart)
形式	buffered aqueous solution
species reactivity	human
包装	vial of 0.1 mL concentrate (357M-14) vial of 0.5 mL concentrate (357M-15) bottle of 1.0 mL predilute (357M-17) vial of 1.0 mL concentrate (357M-16) bottle of 7.0 mL predilute (357M-18)
manufacturer/tradename	Cell Marque?
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
同位素/亚型	IgG
控制	B-cell lymphoma, tonsil
运输	wet ice
储存温度	2-8℃
可视化	cytoplasmic, nuclear