您好,欢迎来到半岛电竞官方网址 ! [ 登录] [ 免费注册]
半岛电竞官方网址
位置: 首页> 品牌> Sigma-Aldrich> SOX-11 (MRQ-58) Mouse Monoclonal Antibody

SOX-11 (MRQ-58) Mouse Monoclonal Antibody

品牌
Sigma-Aldrich
货号
382M-1
包装型号
规格纯度
价格
2993.25 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
SOX-11 (MRQ-58) Mouse Monoclonal Antibody
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Mantle cell lymphoma (MCL) accounts for 5% to 10% of mature B-cell neoplasms and is an aggressive disease genetically characterized by overexpression of cyclin D1 (CCND1), an important regulator of the G1/S phase of the cell cycle, due to the specific translocation t(11;14)(q13;q32). Cyclin D1 overexpression is the hallmark of MCL. However, approximately 5%-10% of MCLs lack cyclin D1 expression and may be misdiagnosed by overreliance on cyclin D1 IHC. Recently, SOX-11 protein expression in MCL has been investigated by immunohistochemistry. Two studies have evaluated SOX-11 expression in MCL and found strong nuclear expression of SOX-11 in almost all cyclin D1-positive MCL (93%-100%). In all 13 cases of cyclin D1-negative MCL, SOX-11 was strongly expressed. The authors also found that blastoid variant of MCL can be differentiated from CD5+ diffuse large B cell lymphoma, which was negative for SOX-11. In summary, nuclear protein expression of SOX-11 is highly associated with both cyclin D1-positive and negative MCL. The detection of this transcription factor is a useful biomarker for identifying true cyclin D1-negative MCL. SOX-11 IHC is of value in further defining pathologic features of CD5+ DLBCL. Routine use of anti-SOX-11 in cases of suspected CD5+ DLBCL might help identify additional cases of cyclin D1-negative blastoid MCL. SOX-11 can also be detected in some BL, LBL and T-PLL, although the different morphological and phenotypic features of these malignancies allow easy recognition of the cases of cyclin D1-negative MCL.

质量


IVD

IVD

IVD

RUO

联系

SOX-11 Positive Control Slides, Product No. 382S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 500
100
生物来源 mouse
偶联物 unconjugated
抗体形式 culture supernatant
antibody product type primary antibodies
克隆 MRQ-58, monoclonal
描述 For In Vitro Diagnostic Use in Select Regions (See Chart)
形式 buffered aqueous solution
species reactivity human
包装 vial of 0.1 mL concentrate (382M-14)
vial of 0.5 mL concentrate (382M-15)
bottle of 1.0 mL predilute (382M-17)
vial of 1.0 mL concentrate (382M-16)
bottle of 7.0 mL predilute (382M-18)
manufacturer/tradename Cell Marque?
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型 IgG1
控制 mantle cell lymphoma
运输 wet ice
储存温度 2-8℃
可视化 nuclear

Sigma-Aldrich

推荐半岛bd体育手机客户端
Baidu
map