S100A1 (EP184) Rabbit Monoclonal Primary Antibody

浜у搧璇存槑

涓€鑸弿杩?/p>

S100A1 is a member of S100 protein family of calcium binding proteins.S100A1 is very useful in the identification of renal cell carcinoma.Published literature indicates that 37 of 40 renal oncocytomas (93%), including two with the tubulo-cystic growth pattern, reacted positively by anti-S100A1.Most of them showed both cytoplasmic and nuclear immunostaining with moderate-to-strong intensity. S100A1 immunostaining was also observed in 30 of 41 clear cell renal cell carcinomas (73%); 6 showed focal positivity, whereas 24 displayed an immunoreactivity ranging from moderate (12 cases) to diffuse (12 cases) expression. Anti-S100A1 detected 30 cases of 32 papillary renal cell carcinomas (94%), 6 showing focal, 12 moderate, and 12 diffuse immunoreactivity. This study also demonstrated that 48 of the 51 chromophobe renal cell carcinomas (94%) showed no labeling by anti-S100A1. In 3 cases of chromophobe renal cell carcinomas (6%) that were positive by anti-S100A1, 2 were classic variant showing scattered S100A1 immunoreactive cells and an eosinophilic variant with nucleocytoplasmic staining in about 40% of the neoplastic cells.Therefore, anti-S100A1 is very useful in the differentiation of renal oncocytoma from chromophobe renal cell carcinoma as well as distinguishing clear cell renal cell carcinoma from chromophobe renal cell carcinoma. S100A1 is detected in normal renal tissue and expressed in both the nuclei and the cytoplasm of the cells lining proximal tubules, loops of Henle, and collecting ducts. The glomerular components are negative. S100A1 is also expressed by skeletal muscle and myocardium; and specific cytoplasmic expression is found in follicular dendritic cells of lymph node.

璐ㄩ噺

IVD

RUO

鑱旂郴

S100A1 Positive Control Slides, Product No. 408S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

澶栧舰

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

鍒跺璇存槑

Download the IFU specific to your product lot and format
Note: This requires a keycode which can be found on your packaging or product label.

Download the latest released IFU
Note: This IFU may not apply to your specific product lot.

鍏朵粬璇存槑

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

娉曞緥淇℃伅

Cell Marque is a trademark of sigma-aldrich Co. LLC

鍩烘湰淇℃伅

NACRES

NA.41

浜у搧鎬ц川

鐢熺墿鏉ユ簮	rabbit
璐ㄩ噺姘村钩	500 100
鍋惰仈鐗?/td>	unconjugated
鎶椾綋褰㈠紡	culture supernatant
antibody product type	primary antibodies
鍏嬮殕	EP184, monoclonal
鎻忚堪	For In Vitro Diagnostic Use in Select Regions (See Chart)
褰㈠紡	buffered aqueous solution
species reactivity	human
鍖呰	vial of 0.1 mL concentrate (408R-14) vial of 0.5 mL concentrate (408R-15) bottle of 1.0 mL predilute (408R-17) vial of 1.0 mL concentrate (408R-16) bottle of 7.0 mL predilute (408R-18)
manufacturer/tradename	Cell Marque^?
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
鍚屼綅绱?浜氬瀷	IgG
鎺у埗	kidney, renal oncocytoma
杩愯緭	wet ice
鍌ㄥ瓨娓╁害	2-8鈩傸/td>
鍙鍖朁/td>	cytoplasmic, nuclear