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位置: 首页> 品牌> Sigma-Aldrich> S100A1 (EP184) Rabbit Monoclonal Primary Antibody

S100A1 (EP184) Rabbit Monoclonal Primary Antibody

品牌
Sigma-Aldrich
货号
408R-1
包装型号
规格纯度
价格
2363.04 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
S100A1 (EP184) Rabbit Monoclonal Primary Antibody
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

S100A1 is a member of S100 protein family of calcium binding proteins.S100A1 is very useful in the identification of renal cell carcinoma.Published literature indicates that 37 of 40 renal oncocytomas (93%), including two with the tubulo-cystic growth pattern, reacted positively by anti-S100A1.Most of them showed both cytoplasmic and nuclear immunostaining with moderate-to-strong intensity. S100A1 immunostaining was also observed in 30 of 41 clear cell renal cell carcinomas (73%); 6 showed focal positivity, whereas 24 displayed an immunoreactivity ranging from moderate (12 cases) to diffuse (12 cases) expression. Anti-S100A1 detected 30 cases of 32 papillary renal cell carcinomas (94%), 6 showing focal, 12 moderate, and 12 diffuse immunoreactivity. This study also demonstrated that 48 of the 51 chromophobe renal cell carcinomas (94%) showed no labeling by anti-S100A1. In 3 cases of chromophobe renal cell carcinomas (6%) that were positive by anti-S100A1, 2 were classic variant showing scattered S100A1 immunoreactive cells and an eosinophilic variant with nucleocytoplasmic staining in about 40% of the neoplastic cells.Therefore, anti-S100A1 is very useful in the differentiation of renal oncocytoma from chromophobe renal cell carcinoma as well as distinguishing clear cell renal cell carcinoma from chromophobe renal cell carcinoma. S100A1 is detected in normal renal tissue and expressed in both the nuclei and the cytoplasm of the cells lining proximal tubules, loops of Henle, and collecting ducts. The glomerular components are negative. S100A1 is also expressed by skeletal muscle and myocardium; and specific cytoplasmic expression is found in follicular dendritic cells of lymph node.

质量


IVD

IVD

IVD

RUO

联系

S100A1 Positive Control Slides, Product No. 408S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律信息

Cell Marque is a trademark of sigma-aldrich Co. LLC

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 500
100
偶联物 unconjugated
抗体形式 culture supernatant
antibody product type primary antibodies
克隆 EP184, monoclonal
描述 For In Vitro Diagnostic Use in Select Regions (See Chart)
形式 buffered aqueous solution
species reactivity human
包装 vial of 0.1 mL concentrate (408R-14)
vial of 0.5 mL concentrate (408R-15)
bottle of 1.0 mL predilute (408R-17)
vial of 1.0 mL concentrate (408R-16)
bottle of 7.0 mL predilute (408R-18)
manufacturer/tradename Cell Marque?
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型 IgG
控制 kidney, renal oncocytoma
运输 wet ice
储存温度 2-8℃
可视化 cytoplasmic, nuclear

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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