NKX3.1 (EP356) Rabbit Monoclonal Primary Antibody

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涓€鑸弿杩?/p>

NKX3.1 is a prostate specific androgen-regulated homeobox gene located on chromosome 8.^1,2,3It is difficult to distinguish between high grade prostate adenocarcinoma and high grade infiltrating urothelial carcinoma using hematoxylin and eosin stained specimens.²Current prostate adenocarcinoma markers such as PSA and PSAP are very useful in determining prostate origin of prostate cancer in other sites, but have lower sensitivity when identifying poorly differentiated compared to well differentiated cases.²Currently, thrombomodulin and uroplakin are used to identify tumors of urothelial origin; however, their sensitivities are suboptimal.²In a study by Gurel et al., nearly all cases of metastatic prostate adenocarcinoma were stained by NKX3.1.¹NKX3.1-positive prostate carcinoma cells exhibit nuclear staining.¹In another study conducted by Chuang et al., nearly all cases of urothelial carcinoma were negative for NKX3.1.²Lastly, NKX3.1 has also been found to be expressed in invasive ductal carcinomas (IDC) and invasive lobular carcinomas (ILC) of the breast.³NKX3.1 expression is limited to ER, PR, and AR positive carcinomas and is more frequently expressed in ILC than IDC.³NKX3.1 has a high specificity and sensitivity for prostate adenocarcinomas and can be used to help distinguish between prostate carcinoma and urothelial carcinomas.^1,2

璐ㄩ噺

IVD

RUO

鑱旂郴

NKX3.1 Positive Control Slides, Product No. 441S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

澶栧舰

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

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NACRES

NA.41

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鐢熺墿鏉ユ簮	rabbit
璐ㄩ噺姘村钩	500 100
鍋惰仈鐗?/td>	unconjugated
鎶椾綋褰㈠紡	culture supernatant
antibody product type	primary antibodies
鍏嬮殕	EP356, monoclonal
鎻忚堪	(For In Vitro Diagnostic Use in Select Regions (See Chart))
褰㈠紡	buffered aqueous solution
species reactivity	human
鍖呰	bottle of 1.0 mL predilute (441R-17) bottle of 7.0 mL predilute (441R-18) vial of 0.1 mL concentrate (441R-14) vial of 0.5 mL concentrate (441R-15) vial of 1.0 mL concentrate (441R-16)
manufacturer/tradename	Cell Marque^?
technique(s)	immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200
鍚屼綅绱?浜氬瀷	IgG
杩愯緭	wet ice
鍌ㄥ瓨娓╁害	2-8鈩傸/td>