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Rhabdomyosarcomas (RMS) are the most frequent malignant soft tissue neoplasms of childhood. While better differentiated RMS have cross-striations or rhabdomyoblasts that allow for a confident morphologic diagnosis, less differentiated RMS resemble other small blue round-cell tumors. MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the myogenic differentiation pathway from the determination of mesodermal precursors into myoblasts, the differentiation of myoblasts into myotubes, and finally the maturation of myotubes into skeletal myofibers. Normal mature skeletal muscle does not express MyoD1 protein. MyoD1 is expressed in myoblasts before differentiation while myogenin has post-differentiation functions. Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase, thus, it is a better biomarker for less differentiated RMS. Studies suggest, anti-MyoD1 may be used together with anti-myogenin and anti-desmin as a panel of markers since any RMS is virtually never negative for all three markers simultaneously.
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 IVD |
 IVD |
 RUO |
鑱旂郴
MyoD1 Positive Control Slides, Product No. 386S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
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Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
鍒跺璇存槑
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鍏朵粬璇存槑
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娉曞緥淇℃伅
Cell Marque is a trademark of sigma-aldrich Co. LLC
浜у搧鎬ц川
| 鐢熺墿鏉ユ簮 | rabbit |
| 璐ㄩ噺姘村钩 | 500 100 |
| 鍋惰仈鐗?/td> | unconjugated |
| 鎶椾綋褰㈠紡 | culture supernatant |
| antibody product type | primary antibodies |
| 鍏嬮殕 | EP212, monoclonal |
| 鎻忚堪 | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| 褰㈠紡 | buffered aqueous solution |
| species reactivity | human |
| 鍖呰 | vial of 0.1 mL concentrate (386R-14) vial of 0.5 mL concentrate (386R-15) bottle of 1.0 mL predilute (386R-17) vial of 1.0 mL concentrate (386R-16) bottle of 7.0 mL predilute (386R-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| 鍚屼綅绱?浜氬瀷 | IgG |
| 鎺у埗 | rhabdomyosarcoma |
| 杩愯緭 | wet ice |
| 鍌ㄥ瓨娓╁害 | 2-8鈩傸/td> |
| 鍙鍖朁/td> | nuclear |
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