半岛bd体育手机客户端 说明
一般描述
Insulin-like growth factor II mRNA binding protein 3 (IMP3) is an oncofetal RNA-binding protein that regulates targets such as insulin-like growth factor-2 and beta-actin. IMP3 expression is at its highest during embryogenesis and silenced in normal human tissues (fibroblasts, lymphocytes, and testes are exceptions).1IMP3 plays a major role in early embryogenesis involving the development of the intestine, thymus, pancreas, and kidneys.2IMP3 mRNA transcript and protein have been demonstrated in high levels in pancreatic cancer tissues but not in benign lesions of the pancreas, chronic pancreatitis, or normal pancreatic tissues.1In a study of IMP3 being used to distinguish between pancreatic ductal adenocarcinoma from chronic sclerosing pancreatitis, IMP3 was found to have high sensitivity and specificity for pancreatic ductal adenocarcinoma and detected pancreatic ductal adenocarcinoma metastases.2IMP3 expression has also been found in a variety of other human cancers including renal cell carcinoma, adenocarcinoma of the uterine cervix, endometrial carcinoma, adenocarcinoma of the esophagus, malignant melanoma, Merkel cell carcinoma, urothelial carcinoma, neuroendocrine carcinoma of the lung, adenocarcinoma of the pancreas, and triple negative breast cancer.1,2
质量
 IVD |
 IVD |
 IVD |
 RUO |
联系
IMP3 Positive Control Slides, Product No. 433S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
半岛bd体育手机客户端 性质
| 生物来源 | rabbit |
| 质量水平 | 500 100 |
| 偶联物 | unconjugated |
| 抗体形式 | culture supernatant |
| antibody product type | primary antibodies |
| 克隆 | EP286, monoclonal |
| 描述 | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | vial of 0.1 mL concentrate (433R-14) vial of 0.5 mL concentrate (433R-15) bottle of 1.0 mL predilute (433R-17) vial of 1.0 mL concentrate (433R-16) bottle of 7.0 mL predilute (433R-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| 同位素/亚型 | IgG |
| 控制 | pancreatic ductal adenocarcinoma, placenta |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| 可视化 | cytoplasmic, membranous |
Sigma-Aldrich
m.cnreagent.com
