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位置: 首页> 品牌> Sigma-Aldrich> Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody

Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody

品牌
Sigma-Aldrich
货号
389M-1
包装型号
规格纯度
价格
2507.44 *本价格含增值税费
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半岛bd体育手机客户端 名称:
Glutamine Synthetase (GS-6) Mouse Monoclonal Antibody
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Glutamine synthetase (GS) catalyzes the synthesis of glutamine from glutamate and ammonia in the mammalian liver.1 In normal liver, GS expression is seen in pericentral hepatocytes, but not in mid-zonal or periportal hepatocytes.1 Glutamine, the end product of GS activity, is the major energy source of tumor cells.1 Based on findings from experimental hepatocarcinogenesis, GS positive tumor cells are believed to be derived from GS positive hepatocytes.1 Thus, anti-GS has been suggested as a marker for hepatocellular carcinoma (HCC).1 GS immunoreactivity has been seen in a majority of HCC (37 of 53 cases, 70%), including 7 of 10 cases of early HCC (70%) and 12 of 22 (59%) for low grade HCC.1 In nonmalignant nodules, GS overexpression was only seen in 3 high grade dysplastic nodules (HGDN,13.6%). In these cases, GS overexpression was restricted to 11.5%-50% of hepatocytes, whereas in HCC the majority of cases (28 of 53, 53%), including early HCC (60%), showed diffuse immunostaining (>50% tumor cells). Overall, the sensitivity, specificity, and positive and negative predictive values of anti-GS for HCC detection were 69.8%, 94.2%, 92.5%, and 75.4%, respectively. A panel composed of antibodies against HSP70, GPC3, and GS has been proposed to be very useful in distinguishing between dysplastic and early malignant hepatocellular nodules arising in cirrhosis. The “all positive” phenotype is restricted to approximately half of early HCC to well-differentiated HCC but has never been reported in dysplastic lesions, whereas the reverse phenotype, “all negative”, has been shown to be a feature of the majority of HGDN and of all low grade dysplastic nodules.

质量


IVD

IVD

IVD

RUO

联系

Glutamine Synthetase Positive Control Slides, Product No. 389S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

制备说明

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其他说明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

质量水平 500
100
生物来源 mouse
偶联物 unconjugated
抗体形式 culture supernatant
antibody product type primary antibodies
克隆 GS-6, monoclonal
描述 For In Vitro Diagnostic Use in Select Regions (See Chart)
形式 buffered aqueous solution
species reactivity human
包装 vial of 0.1 mL concentrate (389M-14)
vial of 0.5 mL concentrate (389M-15)
bottle of 1.0 mL predilute (389M-17)
vial of 1.0 mL concentrate (389M-16)
bottle of 7.0 mL predilute (389M-18)
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100
同位素/亚型 IgG2a
控制 hepatocellular carcinoma
运输 wet ice
储存温度 2-8℃
可视化 cytoplasmic

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