半岛bd体育手机客户端 说明
一般描述
CITED1 is a transcriptional cofactor expressed in the metanephric mesenchyme (MM) of the embryonic kidney and is down-regulated as these cells undergo epithelial differentiation.1-4It is thought that CITED1 may play a role in maintaining MM cells in an undifferentiated state.3Wilms′ tumors (WT) are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed MM within embryonic kidneys.1CITED1 expression has been shown to persist in blastemal cell populations of human WT.1,2In the developing embryonic kidney, CITED1 expression is seen in the cytoplasmic compartment. In WT, expression of CITED1 is detected in the nuclear compartment of tumor cells.1-4It has been suggested that persistent expression of CITED1 in the MM could play a role in WT initiation and pathogenesis.1CITED1 has been detected in 86.8% of WT Cases.2
质量
 IVD |
 IVD |
 IVD |
 RUO |
联系
CITED1 Positive Control Slides, Product No. 424S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
外形
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
制备说明
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其他说明
For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
法律信息
Cell Marque is a trademark of sigma-aldrich Co. LLC
基本信息
| NACRES | NA.41 |
半岛bd体育手机客户端 性质
| 质量水平 | 500 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | ascites fluid |
| antibody product type | primary antibodies |
| 克隆 | 5H6, monoclonal |
| 描述 | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| 形式 | buffered aqueous solution |
| species reactivity | human |
| 包装 | vial of 0.1 mL concentrate (424M-14) vial of 0.5 mL concentrate (424M-15) bottle of 1.0 mL predilute (424M-17) vial of 1.0 mL concentrate (424M-16) bottle of 7.0 mL predilute (424M-18) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| 同位素/亚型 | IgG2aκ |
| 控制 | Wilms’ tumor |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| 可视化 | nuclear |
Sigma-Aldrich
m.cnreagent.com
