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CD7 antigen is a cell surface glycoprotein of 40 kD expressed on the surface of immature and mature T-cells as well as natural Killer (NK) cells. It is a member of the immunoglobulin gene superfamily and is the first T-cell lineage associated antigen to appear in T-cell ontogeny, being expressed in T-cell precursors (preceding CD2 expression), and in myeloid precursors, in fetal liver and bone marrow, and persisting in circulating mature T-cells. While its precise function is not known, it is suggested that the molecule functions as an Fc receptor for IgM. CD7 is the most consistently expressed T-cell antigen in lymphoblastic lymphomas/leukemias, and is therefore anti-CD7 is a useful marker in the identification of such neoplastic proliferations. In mature post-thymic T-cell neoplasms, CD7 is the most common pan-T-antigen to be aberrantly expressed, which is a useful pointer to a neoplastic T-cell process.2,3CD7 has been shown to be immunoexpressed in 85% of mature peripheral T-cells, the majority of post-thymic T-cells, NK cells, T-cell lymphoblastic leukemia/lymphoma, acute myeloid leukemia, and chronic myelogenous leukemia, CD7 is conspicuously absent in adult T-cell leukemia/lymphoma and is not expressed in mycosis fungoides.1-3
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 IVD |
 IVD |
 IVD |
 RUO |
鑱旂郴
CD7 Positive Control Slides, Product No. 107S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).
澶栧舰
Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.
鍒跺璇存槑
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For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com
娉曞緥淇℃伅
Cell Marque is a trademark of sigma-aldrich Co. LLC
鍩烘湰淇℃伅
| NACRES | NA.41 |
浜у搧鎬ц川
| 鐢熺墿鏉ユ簮 | rabbit |
| 璐ㄩ噺姘村钩 | 500 100 |
| 鍋惰仈鐗?/td> | unconjugated |
| 鎶椾綋褰㈠紡 | culture supernatant |
| antibody product type | primary antibodies |
| 鍏嬮殕 | EP132, monoclonal |
| 鎻忚堪 | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| 褰㈠紡 | buffered aqueous solution |
| species reactivity | human |
| 鍖呰 | bottle of 1.0 mL predilute (107R-17) bottle of 7.0 mL predilute (107R-18) vial of 0.1 mL concentrate (107R-14) vial of 0.5 mL concentrate (107R-15) vial of 1.0 mL concentrate (107R-16) |
| manufacturer/tradename | Cell Marque? |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
| 鍚屼綅绱?浜氬瀷 | IgG |
| 杩愯緭 | wet ice |
| 鍌ㄥ瓨娓╁害 | 2-8鈩傸/td> |
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