蛋白质/抗原/多肽 >> 重组蛋白
重组ATP6V0D2蛋白
半岛bd体育手机客户端 介绍
基因名：
Atp6v0d2 半岛bd体育手机客户端 别名： 1620401A02Rik； AI324824； V-ATPase； Atp6v0d2； ATPase, H+ transporting, lysosomal V0 subunit D2； ATPase, H+ transporting, lysosomal V0 subunit D2； V-type proton ATPase subunit d 2； V-ATPase subunit d 2； osteoclast-specific vacuolar ATP synthase； vacuolar proton pump subunit d 2； vacuolar proton-translocating ATPase d subunit d2； ATP6V0D2蛋白； 背景信息：
Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, while F-ATPases reverse the process, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and a integral V0 domain, which is responsible for proton translocation, compose V-ATPase. Nine subunits (A–H) make up the V1 domain and five subunits (a, d, c, c' and c") make up the V0 domain. Like F-ATPase, V-ATPase most likely operates through a rotary mechanism. V-ATPase D2 is a 350 amino acid protein that is expressed in kidney, lung and osteoclast. V-ATPase D2 has been implicated as a regulator of urine acidification, osteoclast fusion and bone formation. Furthermore, V-ATPase D2 has been identified as a dendritic cell marker.
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