蛋白质/抗原/多肽 >> 重组蛋白
重组钙激活钾通道蛋白KCNT2
半岛bd体育手机客户端 介绍
基因名:
Kcnt2 半岛bd体育手机客户端 别名: E330038N15Rik; Slick; Kcnt2; potassium channel, subfamily T, member 2; potassium channel, subfamily T, member 2; potassium channel subfamily T member 2; sodium- and chloride-activated ATP-sensitive potassium channel subunit; 钙激活钾通道蛋白KCNT2; 背景信息:
Voltage-gated K+ channels in the plasma membrane are important regulators of electrical signaling, controlling the repolarization and the frequency of action potentials in neurons, muscles and other excitable cells. KCNT2 is a 1,135 amino acid multi-pass transmembrane protein belonging to the potassium channel family (calcium-activated subfamily) of proteins. KCNT2 produces rapidly activating outward rectifier potassium currents in reponse to high intracellular sodium and chloride levels. Its channel activity is inhibited by ATP, inhalation anesthetics, such as isoflourane, and upon stimulation of G-protein coupled receptors, such as mAChR M1 and GluR-1. There are four isoforms of KCNT2 that are produced as a result of alternative splicing events.
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