蛋白质/抗原/多肽 >> 重组蛋白
重组谷氨酸受体δ2/GluR-δ2蛋白
半岛bd体育手机客户端 介绍
基因名:
Grid2ip 半岛bd体育手机客户端 别名: Grid2ip; glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1; delphilin; GluR-delta2 philic-protein; L-delphilin; glutamate receptor, ionotropic, delta 2-interacting protein 1; 谷氨酸受体δ2/GluR-δ2; 背景信息:
Grid2ip is a postsynaptic scaffolding protein that contains one formin homology 2 (FH2) domain and two PDZ (postsynaptic density-95/discs-large/ZO-1) domains. Expressed in Purkinje cells of the cerebellum and localizing specifically to parallel fiber synapses, Grid2ip interacts with the C-terminus of GluR-Delta 2 and, via this interaction, links GluR-Delta 2 with various signaling molecules and the Actin cytoskeleton. GluR-Delta 2 is a glutamate receptor with an important role in motor learning, cerebellar wiring and synaptic plasticity. Due to alternative splicing events, three Grid2ip isoforms exist, namely L-delphilin, S-delphilin (or delphilin-Alpha) and delphilin-Beta. Each isoform exhibits individual expression patterns and protein interactions. Isoform 2, delphilin-Alpha, is palmytoylated, a modification that is essential for the enhanced expression of GluR-Delta 2 on the cell surface. This modification of delphilin-Alpha also mediates the accumulation of delphilin-Alpha in dendritic spines.
标签:His-tag |
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