蛋白质/抗原/多肽 >> 重组蛋白
重组LULL1蛋白
半岛bd体育手机客户端 介绍
基因名：
TOR1AIP2 半岛bd体育手机客户端 别名： IFRG15； LULL1； NET9； TOR1AIP2； torsin 1A interacting protein 2； torsin 1A interacting protein 2； torsin-1A-interacting protein 2； interferon alpha responsive protein； 15 kDa interferon-responsive protein； interferon responsive gene 15； lumenal domain like LAP1； torsin A interacting protein 2； LULL1蛋白； 耐扭蛋白A相互作用的蛋白2(TOR1AIP2)； 背景信息：
LULL1 is a 470 amino acid endoplasmic reticulum single-pass membrane protein belonging to the TOR1AIP family. LULL1 interacts with torsinA, an essential AAA+ ATPase found in the endoplasmic reticulum (ER) and nuclear envelope (NE) of higher eukaryotes. LULL1 regulates the distribution and activity of torsinA within the ER and NE lumen and reveals functional defects in mutant torsinA, which is responsible for DYT1 dystonia, a neurodevelopmental disease caused by an in-frame deletion (Deltagag) in the gene encoding torsinA. The gene encoding LULL1 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
标签：His-tag |
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