基因名：

DENND2C

产品别名９�p style="text-indent: 2em;">dJ1156J9.1� DENND2C� DENN domain containing 2C� DENN domain containing 2C� DENN domain-containing protein 2C� DENN/MADD domain containing 2C� RP5-1156J9.1� MAP激酶激活死亡域蛋白2C�

背景信息９�div style="text-indent: 2em;">DENND2C is a 928 amino acid protein that contains a dDENN domain, a DENN domain, and a uDENN domain and exists as three isoforms as a result of alternative splicing. The DENND2C protein is thought to target to actin filaments and control Rab9-dependent trafficking of mannose-6-phosphate receptor to lysosomes. The gene encoding DENND2C maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. Other notable genes located on chromosome 1 include LMNA, which is associated with the rare aging disease Hutchinson-Gilford progeria, and the MUTYH gene, which is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome.