蛋白质/抗原/多肽 >> 重组蛋白
重组神经元膜糖蛋白锚定蛋白2
半岛bd体育手机客户端 介绍
基因名:
MDGA2 半岛bd体育手机客户端 别名: MAMDC1; c14_5286; MDGA2; MAM domain containing glycosylphosphatidylinositol anchor 2; MAM domain containing glycosylphosphatidylinositol anchor 2; MAM domain-containing glycosylphosphatidylinositol anchor protein 2; MAM domain containing 1; 神经元膜糖蛋白锚定蛋白2; 背景信息:
MDGA2 is a cell membrane protein which contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single MAM domain. Biochemical characterization demonstrates that MDGA1 and MDGA2 proteins are highly glycosylated, and that MDGA1 is tethered to the cell membrane by a GPI anchor. The MDGAs are differentially expressed by subpopulations of neurons in both the central and peripheral nervous systems, including neurons of the basilar pons, inferior olive, cerebellum, cerebral cortex, olfactory bulb, spinal cord, and dorsal root and trigeminal ganglia. The similarity of MDGAs to other Ig-containing molecules and their temporal-spatial patterns of expression within restricted neuronal populations, for example migrating pontine neurons and D1 spinal interneurons, suggest a role for these novel proteins in regulating neuronal migration, as well as other aspects of neural development, including axon guidance.
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