蛋白质/抗原/多肽 >> 重组蛋白
重组GRB2关联结合蛋白3(GAB3)
半岛bd体育手机客户端 介绍
基因名:
GAB3 半岛bd体育手机客户端 别名: GAB3; GRB2 associated binding protein 3; GRB2 associated binding protein 3; GRB2-associated-binding protein 3; DOS/Gab family member 3; GRB2-associated binder 3; Gab3 scaffolding protein; growth factor receptor bound protein 2-associated protein 3; GRB2关联结合蛋白3(GAB3); 生长因子受体结合蛋白2相关蛋白3; 背景信息:
The Gab family of adaptor proteins function as molecular scaffolds that mediate protein recrutiment to RTKs (1–3). Cytokine/growth factor triggering of protein tyrosine kinase receptors (RTKs) initiates signaling cascades that progress to the nucleus where signals for activation, proliferation and differentiation occur (1–3). This scaffolding mechanism represents a critical link in cytokine/growth factor signaling routes. Gab1-3 contain pleckstrin homology and potential binding sites for SH2 and SH3 domain-containing proteins (1,4,5). The recruitment of signaling partners to Gab family members is phosphorylation dependent (1,4). Insulin receptor and EGF-receptor signaling are among the cascades that rely on Gab family members to elicit a nuclear response to an extracellular stimulus (6,7). The human Gab3 gene maps to chromosome Xq28 and encodes a 586 amino acid protein (5).
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