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蛋白质/抗原/多肽 >> 重组蛋白
重组神经突起生长诱导因子受体UNC5D蛋白
重组神经突起生长诱导因子受体UNC5D蛋白图片
交货期: 1周
索取资料及报价
交货期: 1周
半岛bd体育手机客户端 别名: Recombinant UNC5D
Recombinant unc-5 netrin receptor D protein
半岛bd体育手机客户端 介绍
基因名:

UNC5D


半岛bd体育手机客户端 别名:

PRO34692; Unc5h4; UNC5D; unc-5 netrin receptor D; unc-5 netrin receptor D; netrin receptor UNC5D; netrin receptor Unc5h4; protein unc-5 homolog 4; protein unc-5 homolog D; unc-5 homolog 4; unc-5 homolog D; 神经突起生长诱导因子受体UNC5D;


背景信息:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. Additionally, when cleaved by a caspase to produce an intracellular fragment containing a death domain,UNC5H receptors induce apoptosis. This activity is blocked by the binding of netrin-1. In the absence of netrin-1, UNC5H receptors act as tumor suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumorigenicity. The expression of UNC5H receptors is down-regulated in multiple carcinomas, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. UNC5H4, also known as UNC5D (unc-5 homolog D), is single-pass type I membrane protein that is a member of the UNC5H netrin receptor family. Two isoforms of UNC5H4 exist due to alternative splicing events.

标签:His-tag
分类:Recombinant
类型:Protein
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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