蛋白质/抗原/多肽 >> 重组蛋白
重组刺痛感蛋白
半岛bd体育手机客户端 介绍
基因名:
Prickle1 半岛bd体育手机客户端 别名: 1110058P22Rik; AW215793; Prickle; b2b019Clo; mpk1; Prickle1; prickle planar cell polarity protein 1; prickle planar cell polarity protein 1; prickle-like protein 1; prickle homolog 1; 刺痛感蛋白; 激肽释放酶原(PK); 背景信息:
Prickle1 is an 831 amino acid protein that contains one PET domain and three LIM zinc-binding domains and localizes to the cytoplasm, as well as to the nuclear membrane. Expressed at higher levels in placenta and at lower levels in liver, brain, kidney, lung and pancreas, Prickle1 is thought to function as a nuclear receptor that interacts with NRSF, a silencer protein that binds the DNA sequence element NRSE (neuron-restrictive silencer element). Defects in the gene encoding Prickle1 are associated with autosomal recessive progressive myoclonic epilepsy-1B, which is characterized by quick jerks of the arms, shoulders or legs. The gene encoding Prickle1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome.
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