蛋白质/抗原/多肽 >> 重组蛋白
重组钙依赖分泌激活蛋白2/自闭症的相关蛋白
半岛bd体育手机客户端 介绍
基因名:
CADPS2 半岛bd体育手机客户端 别名: CAPS2; CADPS2; calcium dependent secretion activator 2; calcium dependent secretion activator 2; calcium-dependent secretion activator 2; CAPS-2; Ca++-dependent secretion activator 2; Ca2+ dependent secretion activator 2; Ca2+-dependent activator protein for secretion 2; calcium-dependent activator protein for secretion 2; 钙依赖分泌激活蛋白2/自闭症的相关蛋白; 背景信息:
Calcium-dependent secretion activators (CAPS-1 and CAPS-2) are calcium-binding proteins that direct neurotransmitter and neuropeptide-filled vesicles to the cell membrane for secretory granule exocytosis. Both CAPS-1 and CAPS-2 are expressed primarily in the brain where they regulate the secretion of various substances. The CAPS proteins contain a PH domain that is essential for regulation of exocytosis, as well as regulation of phospholipid binding. Through their regulation of neurotrophin release from granule cells, CAPS proteins help to regulate cell fate during neuronal development. CAPS-1 is thought to regulate catecholamine release from neuronal cells, while CAPS-2 is thought to regulate release of both brain-derived neurotrophic factor and neurotrophin-3 from granule cells. Defects in the genes encoding CAPS-1 and CAPS-2 are implicated in impaired cerebral development and autism.
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