鍩哄洜鍚嶏細

ZNF461

浜у搧鍒悕锛欬p style="text-indent: 2em;">GIOT-1锛 GIOT1锛 HZF28锛 ZNF461锛 zinc finger protein 461锛 zinc finger protein 461锛 zinc finger protein 461锛 gonadotropin-inducible ovary transcription repressor 1锛 zinc finger protein 28锛 閿屾寚铔嬬櫧461锛

鑳屾櫙淇℃伅锛欬div style="text-indent: 2em;">?GIOT-1 is a 563 amino acid protein belonging to the Kr眉ppel C2H2-type zinc-finger protein family. Localized to the nucleus, GIOT-1 is widely expressed in tissues, with highest levels in liver, kidney, small intestine, pancreas and thymus. GIOT-1 contains 12 C2H2-type zinc fincers and one KRAB domain. Because the KRAB domain functions as a transcriptional repressor when attached to the template DNA, GIOT-1 is thought to be involved in transcriptional regulation. The gene encoding GIOT-1 is localized to chromosome 19q13.12 and two isoforms of GIOT-1 exist as a result of alternative splicing events.