半岛bd体育手机客户端 介绍
基因名:
CFAP91 半岛bd体育手机客户端 别名: AAT1; AAT1alpha; C3orf15; CaM-IP2; MAATS1; SPATA26; SPGF51; CFAP91; cilia and flagella associated protein 91; cilia and flagella associated protein 91; cilia- and flagella-associated protein 91; AAT-1; AAT1-alpha; AMY-1-associating protein expressed in testis 1; MYCBP associated and testis expressed 1; MYCBP-associated, testis expressed 1; MYCBP-binding protein; MYCBP/AMY-1-associated testis-expressed protein 1; MYCBP/AMY-1-associated, testis expressed 1; protein MAATS1; spermatogenesis associated 26; 3号染色体开放阅读框15; 背景信息:
The c-Myc proto-oncogene plays a significant role in cell proliferation, differentiation, transformation and apoptosis. A novel c-Myc binding protein, MYCBP (also designated AMY-1), binds to the transactivation domain of c-Myc and stimulates the activation of E-box-dependent transcription. MYCBP translocates from the cytoplasm to the nucleus during S phase when increased expression of c-Myc occurs. MYCBP and AAT-1 (AMY-1-associating protein expressed in testis 1) have been shown to associate with AKAP 149 and AKAP 84 in mitochondria of somatic cells and sperm, which suggests a role for MYCBP and AAT-1 in spermatogenesis. Expression of the AAT-1 gene is regulated by two different promoters, which result in various isoforms. One promoter generates expression of the AAT-1, AAT-1?, AAT-1∫ and AAT-1? isoforms, which are specifically expressed in testis, while the other promoter generates AAT-1L, AAT-1M and AAT-1S, which are differentially expressed.
标签:His-tag |
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