蛋白质/抗原/多肽 >> 重组蛋白
重组环腺苷酸应答元件结合蛋白H
半岛bd体育手机客户端 介绍
基因名:
CREB3L3 半岛bd体育手机客户端 别名: CREB-H; CREBH; HYST1481; HYTG2; CREB3L3; cAMP responsive element binding protein 3 like 3; cAMP responsive element binding protein 3 like 3; cyclic AMP-responsive element-binding protein 3-like protein 3; CREB/ATF family transcription factor; cAMP-responsive element-binding protein, hepatic-specific; 环腺苷酸应答元件结合蛋白H; 背景信息:
CREB3L3 is a 461 amino acid single-pass type II membrane protein that localizes to the endoplasmic reticulum (ER) and, in response to ER stress, is cleaved and translocated to the nucleus. Expressed exclusively in liver, CREB3L3 functions as a transcription factor that, during ER stress, is thought to activate genes that are involved in both the unfolded protein response and the acute phase response (APR). Additionally, CREB3L3 is underexpressed in hepatocellular carcinoma, suggesting a possible role as a tumor suppressor. CREB3L3 functions as a dimer and contains one leucine zipper domain, a KDEL-like sequence and a bZIP domain, through which it conveys its DNA binding ability. Three isoforms of CREB3L3 exist due to alternative splicing events.
标签:His-tag |
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