蛋白质/抗原/多肽 >> 重组蛋白
重组锌指蛋白750
半岛bd体育手机客户端 介绍
基因名:
ZNF750 半岛bd体育手机客户端 别名: SLDPE; ZFP750; ZNF750; zinc finger protein 750; zinc finger protein 750; zinc finger protein 750; protein ZNF750; 锌指蛋白750; 背景信息:
Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 750 is a 723 amino acid member of the Krüppel C2H2-type zinc finger protein family. Localized to the nucleus, ZNF750 contains one conserved C2H2 zinc finger domain and is expressed in the skin, lungs, prostate, placenta and thymus. ZNF750 is also expressed in primary human keratinocytes but not in fibroblasts. Mutations in the gene encoding ZNF750 cause Seborrhea-like dermatitis with psoriasiform, a condition characterized by a chronic and diffuse rash on the face and hyperkeratosis of skin over the elbows, soles, knees and palms.
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