蛋白质/抗原/多肽 >> 重组蛋白
重组FAM83G蛋白
半岛bd体育手机客户端 介绍
基因名:
Fam83g 半岛bd体育手机客户端 别名: 2310040C09Rik; AI506990; wly; Fam83g; family with sequence similarity 83, member G; family with sequence similarity 83, member G; protein FAM83G; FAM83G蛋白; 背景信息:
Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17. The FAM83G gene product has been provisionally designated FAM83G pending further characterization.
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